Key result
Progressive lung mass reduction by >35% at constant pressure increased pulmonary vascular resistance (P<0.05), while capillary filtration coefficient and compliance decreased linearly (P<0.01).
p-value: p=<0.05
In isolated dog lungs, the hemodynamic response to progressive lung mass reduction depends on the perfusion method, with constant flow attenuating the increase in pulmonary vascular resistance through vascular distension.
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Alerts to perfusion method in lung reduction models; hypothesis-generating and should not yet change practice.
Townsley et al. (1987) studied Lung mass reduction (n=20). Progressive lung mass reduction vs. Baseline lung mass was evaluated on Total pulmonary vascular resistance (RT), compliance (CT), and capillary filtration coefficient (Kf,c) (p=<0.05). Progressive lung mass reduction by >35% at constant pressure increased pulmonary vascular resistance (P<0.05), while capillary filtration coefficient and compliance decreased linearly (P<0.01).
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