Key result
Severe edema increased interstitial compliance from 3.54 to 9.12 ml.cmH2O-1.100 g-1 and volume of fluid filtered from 1.28 to 2.4 ml.cmH2O-1.100 g-1, but did not increase capillary filtration coefficient.
The accelerated rate of lobe weight gain during severe pulmonary edema is driven by increased interstitial compliance rather than increased microvascular permeability.
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Compliance may drive pulmonary edema progression; leaves open translation to human lung fluid dynamics.
Parker et al. (1989) studied Pulmonary edema (n=8). Increased capillary pressure (edema formation) vs. Base-line isogravimetric state (mild edema) was evaluated on Capillary filtration coefficient (Kf,C), interstitial compliance (Ci), and volume of fluid filtered (delta Vi). Severe edema increased interstitial compliance from 3.54 to 9.12 ml.cmH2O-1.100 g-1 and volume of fluid filtered from 1.28 to 2.4 ml.cmH2O-1.100 g-1, but did not increase capillary filtration coefficient.
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