Key result
Mitral annular calcification was associated with significantly increased local calcification activity (18F-fluoride tissue-to-background ratio 2.32 vs 1.30) and inflammation compared to patients without calcification.
Why the study?
Mitral annular calcification is associated with cardiovascular events and mitral valve dysfunction, but its underlying pathophysiology remains incompletely understood.
What factors are associated with disease activity and progression in patients with mitral annular calcification?
Cohort (n=104)
What factors are associated with disease activity and progression in patients with mitral annular calcification?
Absolute Event Rate: 2.32% vs 1.3%
p-value: p=<0.001
Mitral annular calcification is characterized by increased local calcification and inflammation, with baseline burden driving disease activity and progression.
No takes yet. Share an insight, caveat, or question.
MAC shows active calcification and inflammation; hypothesis-generating for progression and requires prospective validation before clinical use.
A 2019 study conducted a cohort in Mitral annular calcification (n=104). Mitral annular calcification (MAC) vs. Absence of MAC was evaluated on 18F-fluoride activity (tissue-to-background ratio) (p=<0.001). Mitral annular calcification was associated with significantly increased local calcification activity (18F-fluoride tissue-to-background ratio 2.32 vs 1.30) and inflammation compared to patients without calcification.
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