October 9, 2006British Journal of PharmacologyOpen Access

Iron is not involved in oxidative stress‐mediated cytotoxicity of doxorubicin and bleomycin

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Population

A549 cells (in vitro cell culture model)

Design

Preclinical

Authors

GHGertjan J.M. den HartogMaastricht University TŠTomáš ŠimůnekCharles University LSLadislava SchröterováUniversity Hospital Hradec Králové

Discussion

Member takes

Implication

Questions reliance on iron chelation for anthracycline protection in models; hypothesis-generating for non-iron mechanisms.

Structured PICO

Population

A549 cells (in vitro cell culture model)

Intervention

Five iron chelators (including salicylaldehyde isonicotinoyl hydrazone, deferoxamine, dexrazoxane, monohydroxyethylrutoside) combined with doxorubicin, bleomycin, or H2O2

Outcome

Hydroxyl radical formation, oxidative stress and cellular damage (TBARS formation, GSH consumption, LDH leakage), cell proliferation, and caspase-3 activitysurrogate

The ability to chelate iron is not the sole determinant of protection against doxorubicin or bleomycin-induced cytotoxicity, challenging the putative role of iron in their toxicity.

Cite This Study

Hartog et al. (2006) studied this question.

synapsesocial.com/papers/6a96f00b37dc33ab6afbce15 https://doi.org/10.1038/sj.bjp.0706930

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Ask AI

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Iron is not involved in oxidative stress‐mediated cytotoxicity of doxorubicin and bleomycin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Iron is not involved in oxidative stress‐mediated cytotoxicity of doxorubicin and bleomycin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider