Key result
Complete prenatal closure of the ductus arteriosus in a fetus with transposition of the great arteries resulted in fatal pulmonary hypertension and multi-organ failure.
Why the study?
Prenatal ductus arteriosus restriction can manifest as dangerous persistent pulmonary hypertension in newborns with transposition of the great arteries, potentially related to maternal intake of non-steroidal anti-inflammatory drugs or polyphenols.
Case Report (n=1)
Complete prenatal closure of the ductus arteriosus in a foetus with transposition of the great arteries can lead to fatal persistent pulmonary hypertension.
Prenatal ductal closure may prove fatal in TGA fetuses; leaves open need for prospective fetal monitoring studies.
Prenatal restriction of the ductus arteriosus can manifest as persistent pulmonary hypertension in the newborn, especially dangerous with the transposition of the great arteries. Its aetiology has long been related to maternal intake of non-steroidal anti-inflammatory drugs; however, some other substances, including polyphenols, may have similar properties. We describe a case of complete prenatal closure of the ductus arteriosus in the foetus with transposition of the great arteries. The newborn presented with pulmonary hypertension unresponsive to pharmacotherapy and died of multi-organ failure.
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Grzyb et al. (2020) conducted a case report in Complete prenatal closure of the ductus arteriosus with transposition of the great arteries (n=1). Complete prenatal closure of the ductus arteriosus was evaluated on Clinical outcome. Complete prenatal closure of the ductus arteriosus in a fetus with transposition of the great arteries resulted in fatal pulmonary hypertension and multi-organ failure.
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