Key result
Time-averaged cumulative blood pressure had a U-shaped relationship with adverse outcomes in HFpEF, with the lowest risk at 120-129 mmHg systolic and 70-79 mmHg diastolic.
Why the study?
To determine whether time-averaged cumulative blood pressure is associated with cardiovascular outcomes in patients with heart failure with preserved ejection fraction.
Is time-averaged cumulative blood pressure associated with the risk of cardiovascular outcomes in patients with HFpEF?
Cohort (n=3,330)
Is time-averaged cumulative blood pressure associated with the risk of cardiovascular outcomes in patients with HFpEF?
In patients with HFpEF, time-averaged cumulative blood pressure exhibits a U-shaped relationship with adverse cardiovascular outcomes, with optimal risk at 120-129/70-79 mmHg.
No takes yet. Share an insight, caveat, or question.
Caution against BP extremes in HFpEF; leaves open optimal targets for randomized confirmation.
Huang et al. (2022) conducted a cohort in heart failure with preserved ejection fraction (n=3,330). Time-averaged cumulative blood pressure was evaluated on primary endpoint, all-cause death, cardiovascular death and heart failure hospitalization. Time-averaged cumulative blood pressure had a U-shaped relationship with adverse outcomes in HFpEF, with the lowest risk at 120-129 mmHg systolic and 70-79 mmHg diastolic.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: