Why the study?
Does stimulation with arachidonic acid and TPA increase superoxide generation in immortalized lymphoblasts from hypertensive subjects compared to normotensive subjects?
Does stimulation with arachidonic acid and TPA increase superoxide generation in immortalized lymphoblasts from hypertensive subjects compared to normotensive subjects?
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This editorial highlights that while transformed lymphoblasts from hypertensive patients show increased NAD(P)H oxidase-mediated superoxide generation, definitive understanding of vascular dysfunction requires studies in actual blood vessels.
Julia Brosnan (2002) studied this question.
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