Key result
Maternal age is an independent determinant of plasmin generation in the third trimester, with D-Dimer levels increasing by 2.0 ng/mL for every year increase in age.
Why the study?
Pregnancy, particularly in the third trimester, alters the fibrinolytic system, but the determinants of plasmin generation during this period needed assessment.
Population
41 healthy pregnant women in the third trimester of pregnancy
Comparison
Determinants of D-dimer and PAP complex levels
Design
Cross-sectional study
Authors
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Maternal age may warrant consideration in third-trimester D-dimer interpretation; leaves open effects on VTE risk stratification.
Cross-Sectional (n=41)
No
Effect estimate: Beta 2.0 ng/mL (95% CI 0.4-3.6)
p-value: p=0.031
Maternal age is an independent determinant of plasmin generation markers (D-dimer and PAP complex) during the third trimester of pregnancy, suggesting age should be considered when interpreting these levels.
Okoye et al. (2023) conducted a cross-sectional in Normal pregnancy in the third trimester (n=41). Maternal age was evaluated on Change in D-Dimer levels per year increase in maternal age (Beta 2.0 ng/mL, 95% CI 0.4-3.6, p=0.031). Maternal age is an independent determinant of plasmin generation in the third trimester, with D-Dimer levels increasing by 2.0 ng/mL for every year increase in age.
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