Key result
Inhibition of PAI-1 using catalytic DNA enzymes enhanced bone marrow-dependent neovascularization, cardiomyocyte regeneration, and functional cardiac recovery after myocardial infarction.
Why the study?
Does down-regulation of PAI-1 expression improve myocardial neovascularization and functional recovery in a rat model of myocardial infarction?
Population
Rat model of myocardial infarction
Design
Preclinical
Follow-up
at least 2 wk
Authors
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Hypothesis-generating for PAI-1 inhibition in post-MI repair; human trials needed before clinical consideration.
Does down-regulation of PAI-1 expression improve myocardial neovascularization and functional recovery in a rat model of myocardial infarction?
Down-regulation of PAI-1 expression enhances bone marrow-dependent neovascularization and functional recovery after myocardial infarction in a preclinical model.
Xiang et al. (2004) studied Myocardial infarction. Sequence-specific catalytic DNA enzymes targeting PAI-1 mRNA was evaluated on Postinfarct neovascularization and myocardial function. Inhibition of PAI-1 using catalytic DNA enzymes enhanced bone marrow-dependent neovascularization, cardiomyocyte regeneration, and functional cardiac recovery after myocardial infarction.
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