Key result
The V-index, a novel ECG-based estimator of ventricular repolarization heterogeneity, coherently increased after administration of sotalol (p << 0.001).
Population
Synthetic 12-lead ECGs and 68 real ECGs from the E-OTH-12-0068-010 database of the Telemetric and Holter ECG…
Authors
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V-index may detect drug-induced repolarization changes; hypothesis-generating and requires prospective validation before clinical use.
p-value: p=<< 0.001
The V-index is a novel, biophysically-derived ECG metric that accurately estimates ventricular repolarization heterogeneity and responds to QT-prolonging drugs like sotalol.
Sassi et al. (2011) studied Ventricular repolarization heterogeneity (n=68). Sotalol administration vs. Baseline (pre-administration) was evaluated on V-index (estimator of standard deviation of ventricular myocytes' repolarization times) (p=<< 0.001). The V-index, a novel ECG-based estimator of ventricular repolarization heterogeneity, coherently increased after administration of sotalol (p << 0.001).
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