Key result
Left ventricular hypertrophy in hypertensive patients was associated with significantly lower flow-mediated dilatation compared to hypertensive patients without LVH (4.67% vs 7.02%, P<0.001).
Why the study?
Does the presence of left ventricular hypertrophy worsen endothelial dysfunction in patients with essential hypertension?
Cross-Sectional (n=89)
Does the presence of left ventricular hypertrophy worsen endothelial dysfunction in patients with essential hypertension?
Absolute Event Rate: 4.67% vs 7.02%
p-value: p=<0.001
The presence of left ventricular hypertrophy in essential hypertension is associated with a further significant impairment in vascular endothelial function.
Should not yet change hypertension management; leaves open whether LVH causes or merely marks endothelial impairment.
OBJECTIVE: In this study, we used a non-invasive method in patients with essential hypertension and without any overt clinical evidence of atherosclerosis to investigate the role of left ventricular hypertrophy (LVH) in endothelial functions. METHODS: We assessed endothelial function in 32 hypertensive patients with LVH (group 1), 28 hypertensive patients without LVH (group 2) and 29 normotensive subjects (control group). Flow-mediated (endothelium-dependent) and nitrate induced (endothelium-independent) dilatation of the brachial artery was evaluated in all groups. RESULTS: Flow-mediated dilatation was considerably higher in the control group than in group 1 and 2 (13.98 +/- 2.92%, 4.67 +/- 1.09% and 7.02 +/- 1.79% respectively, p < 0.001). In addition, endothelium-dependent dilatation was significantly lower in group 1 than in group 2 (p < 0.001), whereas nitrate induced changes were similar in all groups. CONCLUSION: Vascular endothelial functions are impaired in hypertensive patients. There may be heterogeneity of endothelial dysfunction among patients with hypertension. Presence of LVH has an additional negative effect on endothelial function in hypertensive patients.
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Ercan et al. (2003) conducted a cross-sectional in Essential hypertension (n=89). Left ventricular hypertrophy vs. Hypertension without LVH and normotensive controls was evaluated on Flow-mediated (endothelium-dependent) dilatation of the brachial artery (p=<0.001). Left ventricular hypertrophy in hypertensive patients was associated with significantly lower flow-mediated dilatation compared to hypertensive patients without LVH (4.67% vs 7.02%, P<0.001).
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