Key result
Current guidelines recommend initial preoperative evaluation with FEV1 and DLco, followed by exercise testing with VO2 max measurement if either parameter is below 80% of the predicted value.
This review outlines the current ERS/ESTS algorithm for preoperative respiratory assessment in lung cancer surgery candidates to minimize perioperative complications.
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Supports guideline-directed FEV1/DLco/VO2max testing before lung resection; leaves open prospective validation of thresholds.
Before planned surgical treatment of lung cancer, the patient's respiratory system function should be evaluated. According to the current guidelines, the assessment should start with measurements of FEV1 (forced expiratory volume in 1 second) and DLco (carbon monoxide lung diffusion capacity). Pneumonectomy is possible when FEV1 and DLco are > 80% of the predicted value (p.v.). If either of these parameters is < 80%, an exercise test with VO2 max (oxygen consumption during maximal exercise) measurement should be performed. When VO2 max is < 35 % p.v. or < 10 ml/kg/min, resection is associated with high risk. If VO2 max is in the range of 35-75% p.v. or 10-20 ml/kg/min, the postoperative values of FEV1 and DLco (ppoFEV1, ppoDLco) should be determined. The exercise test with VO2 max measurement may be replaced with other tests such as the shuttle walk test and the stair climbing test. The distance covered during the shuttle walk test should be > 400 m. Patients considered for lobectomy should be able to climb 3 flights of stairs (12 m) and for pneumonectomy 5 flights of stairs (22 m).
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Trzaska-Sobczak et al. (2014) conducted a review in Lung cancer. Preoperative pulmonary function testing was evaluated. Current guidelines recommend initial preoperative evaluation with FEV1 and DLco, followed by exercise testing with VO2 max measurement if either parameter is below 80% of the predicted value.
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