A Facile Preparation of an Octahydropyrrolo[2,3- c ]pyridine Enantiomer

This is the authors' abstract. We don't add key points for this paper.

A facile synthesis of octahydro-pyrrolo[2,3- c ]pyridine 1 using an intramolecular [3+2]-cycloaddition of an azomethine ylide as the key step and employing DW-therm heat-transfer fluid as a solvent is disclosed. Enantiomerically pure 1 was obtained either via a chromatographic separation of the diastereoisomers 12 and 13 resulting from the cycloaddition with a chiral appendage or by a classical resolution of racemate 19 .