Key result
A collimated x-ray beam delivering 20,000 roentgens to the canine heart produced localized myocardial necrosis by the 7th to 10th post-irradiation day.
Why the study?
Does targeted radiation produce localized myocardial necrosis in intact dogs?
Does targeted radiation produce localized myocardial necrosis in intact dogs?
Targeted high-dose radiation can be used as an experimental technique to produce localized myocardial necrosis in a canine model.
Answers are grounded in this paper and cite their sources.
Enables focal myocardial necrosis models in intact dogs; leaves open human translation pending higher-level evidence.
The radiation effects of 2,500 to 20,000 roentgens on the canine myocardium have been studied. A collimated x-ray beam, 2.54 cm in diameter, was delivered to the heart of 12 dogs at a rate of 210 roentgens per minute. A localized area of myocardial necrosis was evident by the 7th to 10th post-irradiation day in the hearts which received a dose of 20,000 roentgens. Evolution of the myocardial lesion was documented electrocardiographically, and by pathologic examination. Microscopically, the cardiac necrosis was strikingly similar to vascular infarction in the human myocardium. The use of this radiation technique for experimental production of localized myocardial necrosis is discussed.
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Moss et al. (1963) studied Myocardial necrosis (n=12). Collimated x-ray beam was evaluated on Localized myocardial necrosis. A collimated x-ray beam delivering 20,000 roentgens to the canine heart produced localized myocardial necrosis by the 7th to 10th post-irradiation day.
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