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January 1, 1995Journal of the Chemical Society Perkin Transactions 1

Oxidation of some prochiral 3-substituted cyclobutanones using monooxygenase enzymes: a single-step method for the synthesis of optically enriched 3-substituted γ-lactones

René Gagnon Gideon Grogan Esther Groussain S. PEDRAGOSA‐MOREAU Paul Richardson Stanley M. Roberts Andrew Willetts Véronique Alphand Jacques Lebreton Roland Furstoss

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Abstract

Oxidation of the prochiral cyclobutanones 1–5 using Acinetobacter calcoaceticus NCIMB 9871 and Pseudomonas putida NCIMB 10007 monooxygenases (MO1 and MO2) furnishes the corresponding lactones 6–10 in moderate to excellent yield and enantiomeric purity. These enzymes show enantiocomplementarity in all but one case.

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Gagnon et al. (1995) studied this question.

synapsesocial.com/papers/6a973bd4ca6427304e3db4dd https://doi.org/10.1039/p19950002527

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