Key result
Mexiletine administration in 6 patients with ischaemic heart disease left heart rate unchanged, but depressed cardiac function in 3 patients with a history of severe heart failure.
Why the study?
Does mexiletine alter haemodynamic parameters in patients with ischaemic heart disease?
Does mexiletine alter haemodynamic parameters in patients with ischaemic heart disease?
Mexiletine may depress cardiac function in patients with ischaemic heart disease who have a history of severe heart failure.
Caution advised with mexiletine in ischaemic patients with prior severe heart failure; small case series leaves haemodynamic safety open for larger studies.
The haemodynamic effects of mexiletine (Kö 1173) were studied in six patients. Heart rate and cardiac output remained unchanged. The systemic arterial pressure was reduced in two patients owing to a fall in the peripheral resistance. Cardiac function, assessed by means of the stroke work and pulmonary capillary wedge pressure, was depressed in three patients, who all had a current or past history of severe heart failure.
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Kari Saunamäki (1975) studied ischaemic heart disease (n=6). mexiletine (Kö 1173) was evaluated on haemodynamic effects. Mexiletine administration in 6 patients with ischaemic heart disease left heart rate unchanged, but depressed cardiac function in 3 patients with a history of severe heart failure.
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