Key result
Chronic viral infections of the central nervous system, such as subacute sclerosing panencephalitis and Creutzfeldt-Jakob disease, have exceptionally long latent periods due to unusual virus-cell interactions.
Highlights the role of unusual virus-cell interactions in the long latent periods of chronic CNS viral infections in humans and animals.
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May prompt inclusion of rare viral etiologies in CNS differentials; leaves open mechanistic validation beyond observational data.
Several subacute and chronic conditions of the central nervous system (CNS) of man and animals have been found to be of possible viral etiology. In man, these include subacute sclerosing panencephalitis, Creutzfeldt-Jakob disease, and kuru. In animals, scrapie, visna, and lymphocytic choriomeningitis have been transmitted by cell-free filtrates. The techniques of tissue culture, immunofluorescence, and electron microscopy have greatly contributed to a better understanding of the latent and masked viruses which cause these chronic infections of the CNS. The exceptionally long latent or incubation period of these neurological diseases results from an unusual virus-cell interaction.
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Luiz Horta-Barbosa (1971) conducted a review in Chronic viral infections of the central nervous system. Viral etiology was evaluated. Chronic viral infections of the central nervous system, such as subacute sclerosing panencephalitis and Creutzfeldt-Jakob disease, have exceptionally long latent periods due to unusual virus-cell interactions.
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