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Inoculation of tissues from scrapie, kuru, and subacute presenile polioencephalopathy into experimental animals reproduces a similar disease after a prolonged latent period.
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The paper reviews the clinical and pathological similarities between scrapie and kuru and their transmissibility to experimental animals.
Summary The clinical features and the pathological changes in the central nervous system of scrapie and kuru are described and attention is drawn to the similarities between these conditions. In both, inoculation of tissues into experimental animals reproduces a similar disease after a prolonged latent period. The transmission of subacute presenile polioencephalopathy to a chimpanzee is noted. The work which led to the discovery of the transmissibility of these conditions is mentioned.
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Beck et al. (1969) conducted a review in Degenerative diseases of the central nervous system (scrapie, kuru, subacute presenile polioencephalopathy). Inoculation of tissues into experimental animals was evaluated on Transmission of disease. Inoculation of tissues from scrapie, kuru, and subacute presenile polioencephalopathy into experimental animals reproduces a similar disease after a prolonged latent period.
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