Key result
A novel electrocardiogram-synchronized pulsatile mode for continuous-flow LVADs improved pulse pressure to 22.6 mm Hg compared to 11.7 mm Hg with standard continuous mode in an adult goat model.
Why the study?
Does a pulsatile mode of continuous-flow LVADs improve pulsatility compared to continuous mode in an in vivo goat model?
Population
8 adult goats implanted with a centrifugal pump via apex drainage and descending aortic perfusion
Comparison
Pulsatile mode of continuous-flow LVAD vs Continuous mode and Circuit-Clamp
Design
Preclinical
Authors
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Preclinical data only; leaves open whether ECG-synchronized pulsatile LVAD modes improve human outcomes.
Does a pulsatile mode of continuous-flow LVADs improve pulsatility compared to continuous mode in an in vivo goat model?
Absolute Event Rate: 22.6% vs 11.7%
An ECG-synchronized pulsatile mode for continuous-flow LVADs can produce pulsatility comparable to physiological pulsatile flow in an in vivo animal model.
Ando et al. (2011) studied this question. Electrocardiogram-synchronized rotational speed change (pulsatile) mode vs. Continuous mode (constant rotational speed) and Circuit-Clamp was evaluated on Pulse pressure. A novel electrocardiogram-synchronized pulsatile mode for continuous-flow LVADs improved pulse pressure to 22.6 mm Hg compared to 11.7 mm Hg with standard continuous mode in an adult goat model.
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