Key result
Centrifugal-flow left ventricular assist devices generated a significantly higher flow pulsatility index compared to axial-flow pumps under normo-tensive conditions (1.50 vs 0.98, p<0.01).
Why the study?
Do centrifugal-flow continuous-flow ventricular assist devices intrinsically generate a higher pulsatility index compared to axial-flow devices under varying physiologic conditions?
Do centrifugal-flow continuous-flow ventricular assist devices intrinsically generate a higher pulsatility index compared to axial-flow devices under varying physiologic conditions?
Absolute Event Rate: 1.5% vs 0.98%
p-value: p=<0.01
In an in vitro mock circulatory loop, centrifugal-flow LVADs intrinsically generated significantly greater pulsatility than axial-flow LVADs under varying physiologic conditions, which may have implications for reducing suction events.
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May reduce suction events via higher pulsatility with centrifugal-flow LVADs; leaves open clinical translation beyond in vitro conditions.
Stanfield et al. (2013) studied Advanced heart failure (simulated) (n=4). Centrifugal-flow LVADs vs. Axial-flow LVADs was evaluated on Flow pulsatility index (PI) under normo-tensive conditions (p=<0.01). Centrifugal-flow left ventricular assist devices generated a significantly higher flow pulsatility index compared to axial-flow pumps under normo-tensive conditions (1.50 vs 0.98, p<0.01).
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