Key result
Uric acid levels >4.17 mg/dl were significantly associated with decreased IGF-1 standard deviation scores in Chinese adults with type 2 diabetes mellitus (β -0.38; 95% CI -0.64, -0.12; P=0.004).
Why the study?
The relationship between uric acid and insulin-like growth factor-1 in patients with type 2 diabetes mellitus was not well established.
Cross-Sectional (n=1,230)
Effect estimate: β -0.38 (95% CI -0.64, -0.12)
p-value: p=0.004
In Chinese adults with type 2 diabetes, there is a nonlinear relationship between uric acid and IGF-1, with IGF-1 levels decreasing when uric acid exceeds 4.17 mg/dl.
Hypothesis-generating in type 2 diabetes; prospective studies needed before clinical consideration.
Objective: This research examined the relationship between uric acid (UA) and insulin-like growth factor-1 (IGF-1) in patients with type 2 diabetes mellitus (T2DM). Methods: This study was a cross-sectional study that included 1230 Chinese patients with T2DM. We collected general information and laboratory indicators and calculated the standard deviation score of IGF-1 (IGF-1 SDS). Results: The univariate analysis results demonstrated a significant positive relationship between UA levels and IGF-1 SDS ( P < 0.001). A nonlinear relationship was discovered between UA and IGF-1 SDS after adjusting for confounding factors. Multivariate piecewise linear regression showed that the levels of IGF-1 SDS increased when UA was < 4.17 mg/dl (β 0.12,95% CI − 0.04, 0.28; P =0.121) and decreased when UA was > 4.17 mg/dl (β − 0.38,95% CI − 0.64, − 0.12; P =0.004). Conclusion: This study showed a nonlinear relationship between UA and IGF-1 in Chinese adults with T2DM. When the UA levels reached the inflection point, IGF-1 levels negatively correlated with the increase in UA. Further studies are needed to explore this relationship and mechanisms in the future.
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Liu et al. (2021) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=1,230). Uric acid was evaluated on Insulin-like growth factor-1 standard deviation score (IGF-1 SDS) (β -0.38, 95% CI -0.64, -0.12, p=0.004). Uric acid levels >4.17 mg/dl were significantly associated with decreased IGF-1 standard deviation scores in Chinese adults with type 2 diabetes mellitus (β -0.38; 95% CI -0.64, -0.12; P=0.004).
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