Key result
Serum uric acid nonlinearly correlates with higher IGF-1 SDS in children with idiopathic short stature.
Why the study?
Is there a relationship between serum uric acid levels and insulin-like growth factor-1 in Chinese children and adolescents with idiopathic short stature?
Cross-Sectional (n=91)
Is there a relationship between serum uric acid levels and insulin-like growth factor-1 in Chinese children and adolescents with idiopathic short stature?
Effect estimate: β 0.010 (95% CI 0.004-0.017)
p-value: p=0.002
There is a nonlinear relationship between IGF-1 and uric acid levels in Chinese children and adolescents with idiopathic short stature, suggesting appropriate UA levels may have a beneficial effect on IGF-1.
Association in ISS children may reflect metabolic interplay; hypothesis-generating and should not yet change practice.
Objective. The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS).Methods. A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated.Results. A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA ( P=0.004 ). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μmol/L and 301 μmol/L (β0.010, 95% CI 0.004–0.017; P=0.002 ). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μmol/L (β −0.055, 95% CI −0.081–−0.028; P<0.001 ) or more than 301 μmol/L (β −0.005, 95% CI −0.013–0.002; P=0.174 ).Conclusions. This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2018) conducted a cross-sectional in Idiopathic short stature (ISS) (n=91). Serum uric acid (UA) was evaluated on Insulin-like growth factor-1 standard deviation score (IGF-1 SDS) (β 0.010, 95% CI 0.004-0.017, p=0.002). Serum uric acid demonstrated a nonlinear relationship with IGF-1 SDS in children with idiopathic short stature, with IGF-1 SDS increasing when UA was 168-301 μmol/L (β 0.010; P=0.002).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: