Population
Rabbit proximal convoluted tubules
Comparison
90 mosmol hypotonic shock or bath pH increase by… vs Baseline conditions, absence of bicarbonate, or…
Design
Preclinical
Authors
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Hypothesis-generating for proximal tubule volume regulation; extends animal data but leaves open human translation.
In rabbit proximal convoluted tubules, hypotonic shock increases basolateral potassium conductance via a bicarbonate-dependent intracellular alkalinization.
Beck et al. (1992) studied this question.
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