Key result
Cathepsin S expression and elastolytic activity were markedly increased in the left ventricular myocardium of rats and humans with hypertension-induced heart failure compared with controls.
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Hypothesis-generating for cathepsin S in hypertensive heart failure; leaves open its therapeutic targeting pending interventional studies.
Cheng et al. (2006) studied Hypertension-induced left ventricular hypertrophy or heart failure. Hypertension-induced heart failure vs. Hypertrophy or control subjects was evaluated on Cathepsin S mRNA or protein abundance and elastolytic activity. Cathepsin S expression and elastolytic activity were markedly increased in the left ventricular myocardium of rats and humans with hypertension-induced heart failure compared with controls.
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