Key result
TRAPP repair relieved anterior leaflet tenting (28.9° vs 53.5°) and increased anterior central coaptation length (12.7 vs 9.5 mm) compared with annuloplasty in an ex vivo porcine model.
Why the study?
Annuloplasty is ineffective for functional tricuspid regurgitation (FTR) with massive/torrential regurgitation or leaflet tethering, prompting development of TRicuspid Anterior and Posterior Patch (TRAPP) repair.
Does TRAPP repair improve leaflet geometry and coaptation compared to annuloplasty in an ex vivo porcine model of functional tricuspid regurgitation?
Does TRAPP repair improve leaflet geometry and coaptation compared to annuloplasty in an ex vivo porcine model of functional tricuspid regurgitation?
TRAPP repair improves leaflet coaptation and resolves tethering compared to standard annuloplasty in an ex vivo model of functional tricuspid regurgitation, suggesting potential for durable repair in advanced cases.
Should not change tricuspid repair practice; leaves open durability of TRAPP versus annuloplasty in patients.
OBJECTIVE: Annuloplasty is the most common strategy for repair of functional tricuspid regurgitation (FTR) but is not effective in patients with massive/torrential FTR or leaflet tethering. To address the deficits of tricuspid annuloplasty, TRicuspid Anterior and Posterior Patch (TRAPP) repair was developed, which is a pericardial patch augmentation of the anterior and posterior leaflets. METHODS: To test this repair, a previously validated ex vivo model in an explanted porcine heart was used, wherein annular and leaflet geometry were evaluated using a 3-dimensional structured light scanner at 4 time points: (1) baseline, (2) induction of FTR, (3) annuloplasty repair, and (4) patch repair. Annuloplasty increased leaflet tenting angles (anterior: 53.5° vs 41.0°; posterior: 59.7° vs 48.2°; septal: 38.9° vs 31.4°) whereas TRAPP repair relieved anterior and posterior leaflet tenting (anterior: 28.9° vs 41.0°; posterior: 34.9° vs 48.2°; septal: 33.2° vs 31.4°) and restored geometry comparable to the native tricuspid valve. Central coaptation lengths were greater with TRAPP repair than with annuloplasty for all 3 leaflets (anterior: 12.7 vs 9.5 mm; posterior: 12.2 vs 8.2 mm; septal: 7.4 vs 4.6 mm). CONCLUSIONS: Compared with annuloplasty, TRAPP repair yielded greater coaptation length, resolved leaflet tethering, and resulted in a larger annular area that may facilitate durable repair of advanced FTR, which previously would have required replacement.
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Rando et al. (2024) studied Functional tricuspid regurgitation. TRicuspid Anterior and Posterior Patch (TRAPP) repair vs. Annuloplasty was evaluated on Leaflet tenting angles and central coaptation lengths. TRAPP repair relieved anterior leaflet tenting (28.9° vs 53.5°) and increased anterior central coaptation length (12.7 vs 9.5 mm) compared with annuloplasty in an ex vivo porcine model.
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