Key result
Sublingual nitroglycerin significantly decreased blood volume over the thorax (mean 5%, P<0.01) and liver (5%, P<0.05), and increased it over the abdomen (4%, P<0.01) and legs (9%, P<0.01).
Why the study?
Does sublingual nitroglycerin alter the distribution of blood volume in patients with congestive heart failure?
Population
16 patients with congestive heart failure (NYHA class II and III)
Comparison
Sublingual nitroglycerin 0.5 mg vs Placebo
Design
RCT, Randomly assigned
Follow-up
15 minutes
Authors
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Reinforces sublingual nitroglycerin for acute preload reduction in HF; extends evidence on regional blood volume redistribution.
RCT (n=16)
Randomly assigned
Does sublingual nitroglycerin alter the distribution of blood volume in patients with congestive heart failure?
p-value: p=<0.01
Sublingual nitroglycerin causes an immediate redistribution of blood volume from the thorax and liver to the abdomen and legs in patients with congestive heart failure.
Schneider et al. (1987) conducted an RCT in Congestive heart failure (n=16). Nitroglycerin vs. Placebo was evaluated on Percentage changes of baseline value in count rates over thorax, liver, abdomen, and legs (p=<0.01). Sublingual nitroglycerin significantly decreased blood volume over the thorax (mean 5%, P<0.01) and liver (5%, P<0.05), and increased it over the abdomen (4%, P<0.01) and legs (9%, P<0.01).
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