Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: an observational study
View Full Paper
Ask AI
Bookmark
Share
Key result
Higher mean platelet volume was significantly and independently associated with increased coronary artery calcification (β=0.4, p<0.001) in patients without overt cardiovascular disease.
Why the study?
Is mean platelet volume associated with coronary artery calcification in patients without overt cardiovascular disease?
Population
259 participants with at least one cardiac risk factor but with unknown cardiovascular disease, mean age 58…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
May support MPV as a marker of subclinical atherosclerosis; hypothesis-generating and requires prospective validation before clinical use.
Study Design
Type
Observational (n=259)
Multicenter
No
Structured PICO
Is mean platelet volume associated with coronary artery calcification in patients without overt cardiovascular disease?
P
Population
259 adults (mean age 58 years, 56% female) without clinically apparent cardiovascular disease who underwent coronary calcium scoring.
E
Exposure
Mean platelet volume (MPV) measurement
O
Outcome
Coronary artery calcification (CAC) score assessed by multislice computerized tomographysurrogate
Main Result
Effect estimate: β=0.4 (95% CI 19.8-31.1)
p-value: p=<0.001
Higher mean platelet volume is independently associated with increased coronary artery calcification, suggesting it may serve as a marker for atherosclerotic burden in asymptomatic patients.
Limitations
- Modest sample size
- 47% of patients had a calcium score of zero and few had CAC higher than 400
- Retrospective study design
- Did not determine clinical events
- Purely correlative study, so no causative conclusions can be drawn
- 47% of patients had a calcium score of zero and few had CAC >400
- Screening of asymptomatic, low-risk patients
- Retrospective design
Cite This Study
Korkmaz et al. (2012) conducted an observational in No overt cardiovascular disease (n=259). Mean platelet volume was evaluated on Coronary artery calcification (CAC) score (β=0.4, 95% CI 19.8-31.1, p=<0.001). Higher mean platelet volume was significantly and independently associated with increased coronary artery calcification (β=0.4, p<0.001) in patients without overt cardiovascular disease.
Topics
View Full Paper
Ask AI
Bookmark
Share