Key result
Highest mean platelet volume quintile is linked to ~6-fold higher subclinical CAD prevalence.
Why the study?
Several studies have shown a relationship between mean platelet volume and coronary artery disease, but its association with subclinical CAD in asymptomatic individuals was unclear.
Does higher mean platelet volume predict the presence of subclinical coronary artery disease in asymptomatic individuals?
Comparison
Highest quintile of MPV vs lowest quintile of MPV
Design
Cross-sectional study
Authors
Loading...
May support MPV for subclinical CAD risk stratification in asymptomatic adults; hypothesis-generating and requires prospective validation.
Cross-Sectional (n=175)
No
Does higher mean platelet volume predict the presence of subclinical coronary artery disease in asymptomatic individuals?
Odds Ratio: 5.83 (95% CI 1.51–22.42)
Absolute Event Rate: 57.1% vs 24.2%
p-value: p=0.010
Higher mean platelet volume is independently associated with the presence of subclinical coronary artery disease in asymptomatic individuals, suggesting its potential utility as a predictive biomarker.
Chang et al. (2010) conducted a cross-sectional in Subclinical Coronary Artery Disease (n=175). Highest quintile of Mean Platelet Volume (≥11.3 fl) vs. Lowest quintile of Mean Platelet Volume (<9.9 fl) was evaluated on Prevalence of subclinical CAD on MDCT (OR 5.83, 95% CI 1.51-22.42, p=0.010). The highest quintile of mean platelet volume (≥11.3 fl) was independently associated with a significantly higher prevalence of subclinical coronary artery disease compared to the lowest quintile (OR 5.83).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: