Key result
Paclitaxel- and sirolimus-eluting stents were associated with coronary vasoconstriction, whereas biolimus A9, zotarolimus, and bare-metal stents maintained normal vasomotion (P=0.006 proximal, P=0.003 distal).
Why the study?
Do different drug-eluting stents affect endothelium-dependent coronary vasomotion compared to bare-metal stents in patients with implanted coronary stents?
Population
83 patients with implanted coronary stents
Comparison
Drug-eluting stents vs Bare-metal stents
Design
Cohort
Follow-up
9 to 12 months
Authors
Loading...
First-generation DES may impair vasomotion; leaves open effects on clinical outcomes versus newer DES or BMS.
Cohort (n=83)
Do different drug-eluting stents affect endothelium-dependent coronary vasomotion compared to bare-metal stents in patients with implanted coronary stents?
p-value: p=0.006 (proximal), 0.003 (distal)
First-generation drug-eluting stents (paclitaxel, sirolimus) are associated with endothelial dysfunction, whereas newer generation stents (biolimus A9, zotarolimus) preserve endothelial vasomotor response similar to bare-metal stents.
Hamilos et al. (2008) conducted a cohort in Coronary artery disease with implanted stents (n=83). Drug-eluting stents (paclitaxel, sirolimus, biolimus A9, zotarolimus) vs. Bare-metal stents was evaluated on Endothelium-dependent coronary vasomotion of segments proximal and distal to the stent (p=0.006 (proximal), 0.003 (distal)). Paclitaxel- and sirolimus-eluting stents were associated with coronary vasoconstriction, whereas biolimus A9, zotarolimus, and bare-metal stents maintained normal vasomotion (P=0.006 proximal, P=0.003 distal).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: