Key result
Masking positions 1-18 or nucleotides +1 to +4 of the Trypanosoma brucei spliced leader RNA with antisense 2'-O-methyl RNA oligomers completely inhibited trans-splicing.
Population
Permeable Trypanosoma brucei as an in vivo model system for trans-splicing
Design
Preclinical
Authors
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No immediate clinical implications for trypanosomiasis; leaves open these RNA elements as targets for future antiparasitic development.
Antisense 2'-O-methyl RNA oligomers identified two critical functional elements in the Trypanosoma brucei spliced leader RNA required for trans-splicing.
Ullu et al. (1993) studied Trypanosoma brucei trans-splicing. antisense 2'-O-methyl RNA oligomers was evaluated on trans-splicing activity and cap 4 structure modification. Masking positions 1-18 or nucleotides +1 to +4 of the Trypanosoma brucei spliced leader RNA with antisense 2'-O-methyl RNA oligomers completely inhibited trans-splicing.
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