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August 1, 1997American Journal of Perinatology

In Utero Management of Hydrops Fetalis Caused by Critical Aortic Stenosis

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Why the study?

Does prenatal digoxin and postnatal balloon aortic valvuloplasty improve outcomes in fetuses with hydrops fetalis caused by critical valvar aortic stenosis?

Population

2 newborns diagnosed prenatally with hydrops fetalis caused by critical valvar aortic stenosis, with both…

Design

Case_series

Authors

FBFadi BitarBroad InstituteCBCraig ByrumSUNY Upstate Medical UniversityDKDaniel A. KveselisSeattle Children's Hospital

Discussion

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Implication

May support digoxin use for hydrops resolution in critical aortic stenosis; hypothesis-generating and requires prospective validation before practice change.

Structured PICO

Does prenatal digoxin and postnatal balloon aortic valvuloplasty improve outcomes in fetuses with hydrops fetalis caused by critical valvar aortic stenosis?

P
Population
2 newborns diagnosed prenatally with hydrops fetalis caused by critical valvar aortic stenosis, with both left and right ventricular dysfunction.
I
Intervention
Prenatal treatment with digoxin followed by postnatal percutaneous balloon aortic valvuloplasty.
O
Outcome
Resolution of hydrops before delivery and successful postnatal percutaneous balloon aortic valvuloplasty.

Prenatal digoxin therapy may resolve hydrops fetalis caused by critical aortic stenosis, allowing for successful postnatal percutaneous balloon aortic valvuloplasty.

Cite This Study

Bitar et al. (1997) studied this question.

synapsesocial.com/papers/6a9761112c79db18722d113dhttps://doi.org/10.1055/s-2007-994166

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prenatal therapy of non‐immunologic hydrops fetalis caused by severe aortic stenosis2000 · 22 citations
  2. 2Balloon Dilatation of the Aortic Valve in the Fetus2009 · 38 citations
  3. 3Fetal aortic valvuloplasty may rescue fetuses with critical aortic stenosis and hydrops2020 · 19 citations
  4. 4Fetal hydrops due to a tachyarrhythmia progressing to organic pulmonary stenosis2000 · 4 citations
  5. 5Prenatal diagnosis and postnatal management of critical aortic stenosis.1987 · 32 citations