Key result
Fetal aortic valvuloplasty in fetuses with critical aortic stenosis and hydrops led to improved ventricular function and resolution of hydrops in 71.4% of technically successful interventions.
Why the study?
Critical aortic stenosis with a restrictive interatrial septum often leads to fetal congestive heart failure and hydrops, usually culminating in fetal demise if untreated, motivating an evaluation of fetal aortic valvuloplasty.
Does fetal aortic valvuloplasty improve hemodynamics and outcomes in fetuses with critical aortic stenosis and hydrops?
Population
15 fetuses with critical aortic stenosis and signs of hydrops
Comparison
Fetal aortic valvuloplasty
Design
Single-center retrospective review
Authors
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Hypothesis-generating for FAV in hydropic critical aortic stenosis; Level 5 data leaves open need for prospective trials.
Observational (n=15)
No
Does fetal aortic valvuloplasty improve hemodynamics and outcomes in fetuses with critical aortic stenosis and hydrops?
Fetal aortic valvuloplasty can successfully restore fetal cardiac output, resolve hydrops, and achieve a biventricular outcome in fetuses with critical aortic stenosis.
Tulzer et al. (2020) conducted an observational in Critical aortic stenosis and hydrops (n=15). Fetal aortic valvuloplasty was evaluated on Improvement of ventricular function and resolution of hydrops. Fetal aortic valvuloplasty in fetuses with critical aortic stenosis and hydrops led to improved ventricular function and resolution of hydrops in 71.4% of technically successful interventions.
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