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May 29, 2022Journal of Clinical MedicineOpen Access

Intrauterine Valvuloplasty in Severe Aortic Stenosis—A Ten Years Single Center Experience

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Why the study?

To assess the course and outcome of fetal aortic valvuloplasty in fetuses with severe aortic stenosis in a single center.

Population

29 fetuses with severe aortic stenosis

Comparison

Fetal aortic valvuloplasty

Design

Single-center retrospective study

Follow-up

Age of one year

Authors

AWAdeline WalterBSBrigitte StrizekEWEva Weber

Discussion

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Overview

Single-center retrospective FAV data in SAS are hypothesis-generating; prospective multicenter trials needed before practice change.

Structured PICO

P
Population
29 fetuses with severe aortic stenosis (SAS) suitable for fetal aortic valvuloplasty (elevated left ventricular pressures with MR Vmax >250 cm/s and/or AS Vmax >250 cm/s, retrograde flow in the transverse aortic arch, and a left ventricular length Z-score >-1)
I
Intervention
Fetal aortic valvuloplasty (FAV)
O
Outcome
Technical success, survival (live births, infant deaths), and biventricular outcome at one year of agehard clinical

Fetal aortic valvuloplasty for severe aortic stenosis is technically feasible with low procedure-related mortality, but achieves biventricular circulation in only about half of survivors at one year.

Limitations

  • Single center experience
  • Retrospective design
  • Absence of randomized controlled trials

Cite This Study

Walter et al. (2022) studied this question.

synapsesocial.com/papers/6a715bf0febe604dd70a081ehttps://doi.org/10.3390/jcm11113058
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Postnatal outcome following fetal aortic valvuloplasty for critical aortic stenosis2024 · 9 citations
  2. 2Valvuloplasty in 103 fetuses with critical aortic stenosis: outcome and new predictors for postnatal circulation2021 · 58 citations
  3. 3Procedural, pregnancy, and short‐term outcomes after fetal aortic valvuloplasty2020 · 36 citations
  4. 4Fetal aortic valvuloplasty may rescue fetuses with critical aortic stenosis and hydrops2020 · 18 citations
  5. 5Intrauterine aortic valvuloplasty in fetuses with critical aortic stenosis: experience and results of 24 procedures2011 · 137 citations