Key result
The highest quartile of fatty liver index was associated with a significantly increased risk of new-onset heart failure compared to the lowest quartile (HR 2.709) in healthy adults.
Why the study?
The association between nonalcoholic fatty liver disease and heart failure had not been evaluated in a large-scale cohort study.
Does a higher fatty liver index predict the development of new-onset heart failure in healthy adults?
Population
308,578 healthy persons without comorbidities in the Republic of Korea
Comparison
Quartile groups according to fatty liver index
Design
Nationwide population-based cohort study
Follow-up
Median of 5.4 years
Authors
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Higher FLI may flag HF risk in healthy adults; hypothesis-generating for NAFLD contribution and needs prospective validation before practice change.
Cohort (n=308,578)
Does a higher fatty liver index predict the development of new-onset heart failure in healthy adults?
Hazard Ratio: 2.709 (95% CI 2.38–3.085)
Absolute Event Rate: 1.2% vs 0.4%
p-value: p=<0.001
A higher fatty liver index is independently associated with an increased risk of new-onset heart failure in healthy adults, suggesting non-alcoholic fatty liver disease may contribute to heart failure development even in the absence of traditional cardiovascular comorbidities.
Roh et al. (2020) conducted a cohort in Healthy adults (evaluating new-onset heart failure) (n=308,578). Higher fatty liver index (FLI) vs. Lowest fatty liver index (FLI) quartile was evaluated on Incidence of new-onset heart failure (HR 2.709, 95% CI 2.380-3.085, p=<0.001). The highest quartile of fatty liver index was associated with a significantly increased risk of new-onset heart failure compared to the lowest quartile (HR 2.709) in healthy adults.
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