Key result
The highest quartile of fatty liver index was independently associated with an increased risk of new-onset hypertension compared to the lowest quartile (adjusted HR 2.330).
Why the study?
Little data existed from large-scale cohort studies evaluating the association between nonalcoholic fatty liver disease and hypertension, prompting investigation into whether the fatty liver index predicts new-onset hypertension.
Does a higher Fatty Liver Index predict new-onset hypertension in healthy adults?
Population
334,280 healthy individuals without known comorbidities undergoing National Health check-ups in South Korea
Comparison
Quartiles of fatty liver index
Design
Cohort study
Follow-up
Median of 5.2 years
Authors
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FLI may identify adults at higher hypertension risk; leaves open incremental value beyond established predictors.
Cohort (n=334,280)
Does a higher Fatty Liver Index predict new-onset hypertension in healthy adults?
Hazard Ratio: 2.33 (95% CI 2.218–2.448)
Absolute Event Rate: 11.9% vs 2.7%
p-value: p=<0.001
A higher Fatty Liver Index is independently associated with an increased risk of new-onset hypertension in healthy adults, suggesting its utility as a predictor for cardiovascular risk.
Roh et al. (2020) conducted a cohort in New-onset hypertension (n=334,280). Highest quartile of fatty liver index (FLI >31.0) vs. Lowest quartile of fatty liver index (FLI 0-4.9) was evaluated on Incidence of new-onset hypertension (HR 2.330, 95% CI 2.218-2.448, p=<0.001). The highest quartile of fatty liver index was independently associated with an increased risk of new-onset hypertension compared to the lowest quartile (adjusted HR 2.330).
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