Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 7, 2020Open Access

Higher fatty liver index is associated with increased risk of new onset heart failure in healthy adults: A nationwide population-based study in Korea

View Full Paper
Ask AI
Bookmark
Share

Key result

The highest quartile of fatty liver index was independently associated with a significantly increased risk of new-onset heart failure compared to the lowest quartile (HR 2.709) in healthy adults.

Why the study?

Although heart failure is associated with many cardiovascular risk factors, the association between nonalcoholic fatty liver disease and heart failure had not been evaluated in a large-scale cohort study.

Does a higher fatty liver index predict the development of new-onset heart failure in healthy adults?

Population

308,578 healthy persons without comorbidities undergoing National Health check-ups in Korea

Comparison

Quartiles of fatty liver index (FLI Q1 to Q4)

Design

Nationwide population-based cohort study

Follow-up

Median of 5.4 years

Authors

JRJae‐Hyung RohInterventional / Structural CardiologyJPJae‐Hyeong ParkCardiac ImagingHLHanbyul LeeSamsung (South Korea)

Discussion

Loading...

Member takes

Implication

FLI may refine HF risk prediction in primary prevention; leaves open whether NAFLD modification prevents incident HF.

Study Design

Type

Cohort (n=308,578)

Structured PICO

Does a higher fatty liver index predict the development of new-onset heart failure in healthy adults?

P
Population
308,578 healthy Korean adults without known cardiovascular risk factors or comorbidities, followed for a median of 5.4 years to assess the incidence of new-onset heart failure.
E
Exposure
Highest quartile of Fatty Liver Index (FLI >31.0), a surrogate marker for non-alcoholic fatty liver disease
C
Comparator
Lowest quartile of Fatty Liver Index (FLI 0-4.9)
O
Outcome
Incidence of new-onset heart failure (defined as the first occurrence during at least 2 different days of hospital visits, at HF admission, or death with a diagnosis of HF) at median 5.4 years follow-uphard clinical

Main Result

Hazard Ratio: 2.709 (95% CI 2.38–3.085)

Absolute Event Rate: 1.2% vs 0.4%

p-value: p=<0.001

A higher Fatty Liver Index, a surrogate marker for non-alcoholic fatty liver disease, is independently associated with an increased risk of developing new-onset heart failure in healthy adults.

Limitations

  • Analyzed only claims data and National Health Screening data without echocardiographic or chemical data
  • Estimated new onset HF by using ICD-10 disease code, and the accuracy of HF diagnosis was not validated
  • Observational study design cannot show other contributable factors in the development of HF
  • Study population included only Koreans, limiting generalization to other ethnic populations
  • Analyzed only claims data and National Health Screening data without echocardiographic or chemical data (accuracy of HF diagnosis not validated)
  • Study population included only Koreans, requiring caution in generalization to other ethnic populations

Cite This Study

Roh et al. (2020) conducted a cohort in Healthy adults (n=308,578). Higher fatty liver index (FLI) vs. Lowest fatty liver index (FLI Q1) was evaluated on Incidence of new-onset heart failure (HR 2.709, 95% CI 2.380-3.085, p=<0.001). The highest quartile of fatty liver index was independently associated with a significantly increased risk of new-onset heart failure compared to the lowest quartile (HR 2.709) in healthy adults.

synapsesocial.com/papers/6a977518883af1d6c8a66a56https://doi.org/10.21203/rs.2.17577/v2
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of non‐alcoholic fatty liver disease on left ventricular diastolic function and geometry in the Korean general population2016 · 44 citations
  2. 2Epidemiology of Heart Failure in Korea: Present and Future2016 · 132 citations
  3. 3Fibrosis stage is the strongest predictor for disease‐specific mortality in NAFLD after up to 33 years of follow‐up2014 · 2,309 citations
  4. 4Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells2013 · 114 citations
  5. 5Cohort Profile: The National Health Insurance Service–National Sample Cohort (NHIS-NSC), South Korea2016 · 1,506 citations