Key result
Natural exposure to wild poliovirus in unimmunized preschool children in rural Ghana led to increasing seropositivity after 9 months of age, following a nadir of 28%, 44%, and 12% at 4-9 months.
Cross-Sectional
No
The presence of neutralizing antibodies against poliovirus in unimmunized preschool children confirms endemic community spread of the virus in rural Ghana prior to active immunization.
Answers are grounded in this paper and cite their sources.
Signals endemic wild poliovirus circulation in rural Ghana; leaves open optimal early immunization timing pending prospective data.
The finding of the neutralizing antibodies against poliovirus in unimmunized preschool children confirms the endemicity of the disease in the rural community. The predominant polio antibody types were types 1 and 2. In children under 4 months of age, 82% were seropositive to type 1, 91% to polio type 2 and 55% to polio type 3; evidence of maternal transplacental antibodies. There were fewer seropositives in the age group 4-9 months, 28%, 44% and 12% to the types 1, 2 and 3, respectively. However, the percentages of seropositives to all three types increased for the rest of the age groups, indicating possible contact with the wild poliovirus in early infancy. Community spread of the virus is also supported by the intrafamilial clustering of the seropositives.
No takes yet. Share an insight, caveat, or question.
Isomura et al. (1987) conducted a cross-sectional in Poliovirus. Natural poliovirus exposure was evaluated on Seropositivity to polio antibody types 1, 2, and 3. Natural exposure to wild poliovirus in unimmunized preschool children in rural Ghana led to increasing seropositivity after 9 months of age, following a nadir of 28%, 44%, and 12% at 4-9 months.
Synapse has enriched 10 related papers. Consider them for comparative context: