Key result
Global longitudinal strain measured by 4D flow CMR and CT correlated well with speckle-tracking echocardiography (Pearson's r 0.67 and 0.65, respectively; p < 0.001).
Why the study?
LVGLS is most often measured using speckle-tracking TTE, motivating evaluation of a novel feature-tracking approach on 4D flow CMR compared with dynamic CT and speckle-tracking TTE.
Does LVGLS measurement using 4D flow CMR and CT correlate with speckle-tracking TTE in adult patients with bicuspid aortic valves?
Population
59 consecutive adult patients with a bicuspid aortic valve
Comparison
4D flow CMR vs dynamic CT vs speckle-tracking TTE
Design
Prospective cohort study
Authors
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May support combined flow-function assessment by CMR in BAV; leaves open outcome validation versus TTE.
Cohort (n=59)
Blinded to other modalities
No
Does LVGLS measurement using 4D flow CMR and CT correlate with speckle-tracking TTE in adult patients with bicuspid aortic valves?
Effect estimate: Pearson's r: 0.67 for CMR vs TTE, 0.65 for CT vs TTE
p-value: p=<0.001
Feature-tracking GLS analysis using magnitude images from 4D flow CMR is feasible and correlates well with CT and speckle-tracking TTE, allowing for an integrative assessment of flow and function in a single sequence.
Hoven et al. (2020) conducted a cohort in Bicuspid aortic valve (n=59). 4D flow cardiovascular magnetic resonance (CMR) and computed tomography (CT) vs. Speckle-tracking transthoracic echocardiography (TTE) was evaluated on Correlation of global longitudinal strain (GLS) between CMR/CT and TTE (Pearson's r: 0.67 for CMR vs TTE, 0.65 for CT vs TTE, p=<0.001). Global longitudinal strain measured by 4D flow CMR and CT correlated well with speckle-tracking echocardiography (Pearson's r 0.67 and 0.65, respectively; p < 0.001).
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