Key result
COVID-19 patients exhibited significantly prolonged mean QTc intervals (410.8 vs 394.6 msec, p<0.001) and elevated Tpe/QTc and QTd values compared to healthy controls.
Why the study?
The study was conducted to evaluate the malignant arrhythmic potential of COVID-19 using surface electrocardiographic indicators.
Does COVID-19 infection increase surface ECG predictors of malignant arrhythmia compared to healthy controls?
Cross-Sectional (n=91)
Blinded assessors
No
Does COVID-19 infection increase surface ECG predictors of malignant arrhythmia compared to healthy controls?
Absolute Event Rate: 410.8% vs 394.6%
p-value: p=<0.001
COVID-19 infection is associated with prolonged QTc and increased Tpe/QTc ratio, suggesting an elevated risk for malignant ventricular arrhythmias.
Hypothesis-generating for arrhythmia risk in COVID-19; prospective studies needed before clinical adoption.
Background: The goal was to use surface electrocardiographic (ECG) indicators to detect COVID-19's malignant arrhythmic potential. Methodology: In 51 COVID-19 patients and 40 control subjects, the ECG parameters PR, QT, QTc, QTd, TPe, and Tpe/QTc were assessed. COVID-19 patients had substantially higher mean QTc (410.8 24.3 msec vs. 394.6 20.3 msec, p.001), Tpe/QTc (0.19 0.02 vs. 0.18 0.04, p =.036), and median QTd (47.52 vs. 46.5) values than the control group. Troponin levels were linked with heart rate (r = 0.387, p =.006) but not with ECG parameters (r = 0.387, p =.006). Conclusion: In Covid19 patients, several ventricular arrhythmia surface ECG predictors, such as QTc, QTd, and Tpe/QTc, are elevated. Because drugs used in COVID-19 patients have the potential to impact these parameters.
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Khaled Hassan (2021) conducted a cross-sectional in COVID-19 (n=91). COVID-19 infection vs. Healthy control group was evaluated on Mean QTc interval (msec) (p=<0.001). COVID-19 patients exhibited significantly prolonged mean QTc intervals (410.8 vs 394.6 msec, p<0.001) and elevated Tpe/QTc and QTd values compared to healthy controls.
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