Key result
COVID-19 patients exhibited significantly higher mean QTc (410.8 vs. 394.6 msec, p<.001) and Tpe/QTc (0.19 vs. 0.18, p=0.036) compared to control subjects.
Why the study?
The study aimed to detect the malignant arrhythmic potential of COVID-19 using surface electrocardiographic markers.
Does COVID-19 infection increase malignant arrhythmic potential as measured by surface ECG markers compared to control subjects?
Case-Control (n=91)
Does COVID-19 infection increase malignant arrhythmic potential as measured by surface ECG markers compared to control subjects?
Absolute Event Rate: 410.8% vs 394.6%
p-value: p=<.001
COVID-19 patients exhibit increased surface ECG markers of ventricular arrhythmia, such as QTc and Tpe/QTc, suggesting a higher arrhythmogenic potential.
May signal higher arrhythmic risk in COVID-19; hypothesis-generating and leaves open clinical relevance.
Objective We aimed to detect the malignant arrhythmic potential of COVID-19 with surface electrocardiographic (ECG) markers.Material and method Of the ECG parameters PR, QT, QTc, QTd, TPe, and Tpe/QTc were measured in 51 COVID-19 patients and 40 in control subjects.Results Compared to control group mean QTc (410.8 ± 24.3 msec vs. 394.6 ± 20.3 msec, p < .001) and Tpe/QTc (0.19 ± 0.02 vs. 0.18 ± 0.04, p = .036) and median QTd (47.52 vs. 46.5) values were significantly higher in COVID-19 patients. Troponin levels were significantly correlated with heart rate (r = 0.387, p = .006) but not with ECG parameters.Conclusion Several ventricular arrhythmia surface ECG predictors including QTc, QTd, and Tpe/QTc are increased in COVID-19 patients. Since medications used in COVID-19 patients have the potential to affect these parameters, giving importance to these ECG markers may have a significant contribution in decreasing disease-related arrhythmias.
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Öztürk et al. (2020) conducted a case-control in COVID-19 (n=91). COVID-19 disease vs. Control subjects was evaluated on mean QTc (msec) (p=<.001). COVID-19 patients exhibited significantly higher mean QTc (410.8 vs. 394.6 msec, p<.001) and Tpe/QTc (0.19 vs. 0.18, p=0.036) compared to control subjects.
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