Organic fluorine as crystal engineering tool: Evidence from packing features in fluorine substituted isoquinolines

The crystal structures of six newly synthesized compounds, based on the molecular motif, 6-methoxy 1,2-diphenyl-1,2,3,4-tetrahydroisoquinoline, with different fluoro substitution in 1-phenyl and/or 2-phenyl ring(s) have been reported. Structure determination at 100.0(2) K ensures the accuracy of the evaluation of intermolecular interactions involving F and H atoms. These structures display different packing features by generating molecular motifs via C–F⋯F, C–H⋯F and C–H⋯O interactions in the crystal lattice. The changes in both conformational features and in the intra- and intermolecular interactions involving fluorine provide significant inputs for understanding packing features associated with organic fluorine.