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Investigate the regulatory effect of serotonin and its precursor on the secretion of vasoactive intestinal polypeptide into rat hypophysial portal blood.

July 1, 1982Endocrinology

Stimulation by Serotonin of Vasoactive Intestinal Polypeptide Release Into Rat Hypophysial Portal Blood

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Investigate the regulatory effect of serotonin and its precursor on the secretion of vasoactive intestinal polypeptide into rat hypophysial portal blood.
Administered serotonin intraventricularly (2 and 10 μg/rat) or L-5-hydroxytryptophan intravenously (1 mg/100 g BW) to urethane-anesthetized rats, alongside saline controls.
Sampled hypophysial portal blood through a parapharyngeal surgical approach and quantified plasma VIP concentrations using radioimmunoassay.
Mean (± SE) basal plasma VIP was 1799 ± 232 pg/ml, which slightly decreased during vehicle control experiments.
Intraventricular serotonin significantly increased plasma VIP concentrations within 20 minutes, and intravenous L-5-HTP similarly elevated portal VIP without altering blood flow rate.

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Implication

Laboratory study reveals increased portal vasoactive intestinal polypeptide after serotonin delivery in rats, suggesting serotonergic control of pituitary signaling.

Cite This Study

Shimatsu et al. (1982) studied this question.

synapsesocial.com/papers/6a9784101bbe0b4ddca65f08 https://doi.org/10.1210/endo-111-1-338

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Implication

Laboratory study reveals increased portal vasoactive intestinal polypeptide after serotonin delivery in rats, suggesting serotonergic control of pituitary signaling.

Stimulation by Serotonin of Vasoactive Intestinal Polypeptide Release Into Rat Hypophysial Portal Blood

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Discussion

Implication

Cite This Study

Stimulation by Serotonin of Vasoactive Intestinal Polypeptide Release Into Rat Hypophysial Portal Blood

Key Points

Discussion

Implication

Cite This Study

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