Key result
VIP infusion in conscious rabbits produced a 2-3 fold rise in plasma renin activity and a 50% increase in heart rate, with the renin response being inhibited by indomethacin.
Why the study?
Does vasoactive intestinal polypeptide (VIP) infusion increase plasma renin activity and heart rate in conscious rabbits?
Does vasoactive intestinal polypeptide (VIP) infusion increase plasma renin activity and heart rate in conscious rabbits?
The renin response to VIP in conscious rabbits is partly prostaglandin-dependent, while the heart rate response is mediated by beta-adrenoceptor stimulation.
Answers are grounded in this paper and cite their sources.
VIP effects on renin in rabbits are partly prostaglandin-dependent; leaves open translation to human cardiovascular regulation.
Vasoactive intestinal polypeptide (VIP) has been found within the renal cortex and is believed to be a neurotransmitter. Although it produces systemic vasodilatation and renin release, the exact mechanism of the latter response is uncertain. When infused into conscious rabbits, VIP elicits a rise in plasma renin activity (PRA) and an increase in heart rate. The rise in PRA is unaltered by pretreatment with propranolol, but is attenuated by indomethacin. The tachycardia is inhibited by propranolol, but unaffected by indomethacin. We conclude that the renin response to VIP is in part prostaglandin-dependent and that the heart rate response is due to direct or reflex beta-adrenoceptor stimulation.
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Calam et al. (1983) studied Healthy conscious rabbits (n=9). Vasoactive intestinal polypeptide (VIP) vs. Vehicle alone (baseline) was evaluated on Plasma renin activity (PRA) (2-3 fold rise, p=<0.001). VIP infusion in conscious rabbits produced a 2-3 fold rise in plasma renin activity and a 50% increase in heart rate, with the renin response being inhibited by indomethacin.
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