Key result
Systolic blood pressure of 120-130 mmHg was associated with a higher risk of subarachnoid haemorrhage compared to <120 mmHg (HR 1.41; 95% CI 1.02-1.95), with risk increasing at higher thresholds.
Why the study?
Hypertension is an established risk factor for subarachnoid haemorrhage, but the precise relationship between blood pressure levels and subarachnoid haemorrhage warranted further characterization.
Does maintaining systolic blood pressure <120 mmHg reduce the risk of aneurysmal subarachnoid haemorrhage compared to higher blood pressure thresholds in the general population?
Cohort (n=500,598)
Does maintaining systolic blood pressure <120 mmHg reduce the risk of aneurysmal subarachnoid haemorrhage compared to higher blood pressure thresholds in the general population?
Hazard Ratio: 1.41 (95% CI 1.02–1.95)
The risk of aneurysmal subarachnoid haemorrhage increases linearly with higher systolic blood pressure, with the lowest risk observed at SBP <120 mmHg, suggesting benefits of stricter blood pressure control.
No takes yet. Share an insight, caveat, or question.
SBP <120 mmHg was associated with lower SAH risk; extends linear association but leaves open whether targeting it prevents events.
Ewbank et al. (2023) conducted a cohort in Subarachnoid haemorrhage (n=500,598). Systolic blood pressure 120-130 mmHg vs. Systolic blood pressure <120 mmHg was evaluated on Aneurysmal subarachnoid haemorrhage (HR 1.41, 95% CI 1.02-1.95). Systolic blood pressure of 120-130 mmHg was associated with a higher risk of subarachnoid haemorrhage compared to <120 mmHg (HR 1.41; 95% CI 1.02-1.95), with risk increasing at higher thresholds.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: