Key result
Necropsy of 116 children dying with leukemia revealed leukemic cardiac infiltration in 44% of patients and significant cardiac hypertrophy in 33 of 99 evaluated hearts.
Observational (n=116)
Necropsy studies of children dying with leukemia demonstrate a high incidence of leukemic cardiac infiltration and cardiac hypertrophy, the latter likely driven by chronic anemia.
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Cardiac infiltration may contribute to mortality in fatal pediatric leukemia; hypothesis-generating for prospective cardiac monitoring studies.
Sumners et al. (1969) conducted an observational in Leukemia (n=116). Leukemia was evaluated on Leukemic cardiac infiltration. Necropsy of 116 children dying with leukemia revealed leukemic cardiac infiltration in 44% of patients and significant cardiac hypertrophy in 33 of 99 evaluated hearts.
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