Key result
Alpha 1-adrenoceptors are functionally predominant in rabbit peripheral arteries, and alpha 2-adrenoceptor agonist-induced vasodilation may be due to antagonism of alpha 1-mediated constrictions.
This preclinical study demonstrates that alpha 1-adrenoceptors are functionally predominant in rabbit peripheral arteries and highlights regional differences in the vascular effects of clonidine.
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Rabbit artery findings should not guide human alpha-agonist use; leaves open species-specific adrenoceptor mechanisms.
Fujiwara et al. (1993) studied this question. Alpha-adrenoceptor agonists (phenylephrine, methoxamine, clonidine, xylazine) was evaluated on Vascular responsiveness (vasoconstriction and vasodilation). Alpha 1-adrenoceptors are functionally predominant in rabbit peripheral arteries, and alpha 2-adrenoceptor agonist-induced vasodilation may be due to antagonism of alpha 1-mediated constrictions.
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