Percutaneous Left Atrial Appendage Closure for Non-Valvular Atrial Fibrillation

peutic range, the need for lifelong anticoagulation monitoring, and multiple drug and food interactions, which was the impetus for the development of NOACs (nonwarfarin oral anticoagulants). LAAC is now performed across the world. The procedure prevents thromboembolism, particularly ischemic cardioembolic stroke, by occluding the LAA orifice with a specific device, because transesophageal echocardiography and autopsy studies suggested the LAA is the major source of thromboembolism in patients with NVAF, which led to the eft atrial appendage closure (LAAC) has proven its safety as an effective alternative to warfarin for stroke prevention in patients with nonvalvular atrial fibrillation (NVAF).