Key result
Dihydropyridine calcium antagonists inhibit stimulus-dependent calcium entry into arterial cells, with their potency highly dependent on resting membrane potential and depolarizing stimulus duration.
Population
Arterial cells (experimental models)
Design
Review
Authors
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Highlights context-dependent dihydropyridine potency in vitro; leaves open clinical translation to arterial tone regulation.
The pharmacological potency of dihydropyridine calcium antagonists in arterial cells is modulated by resting membrane potential and depolarizing stimulus duration.
Godfraind et al. (2008) reported a review. Calcium antagonists (dihydropyridines) was evaluated. Dihydropyridine calcium antagonists inhibit stimulus-dependent calcium entry into arterial cells, with their potency highly dependent on resting membrane potential and depolarizing stimulus duration.
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