Key result
Lidocaine significantly decreased the induced rises in heart rate, forearm vascular resistance, plasma noradrenaline, and plasma renin activity during high-level simulated orthostatic stress (p<0.05).
Why the study?
Does lidocaine infusion alter cardiovascular reflex responses to simulated orthostatic stress in healthy volunteers?
Population
Healthy volunteers
Comparison
Lidocaine infusion vs Saline infusion
Design
Other
Authors
Loading...
May warrant caution with lidocaine in patients with impaired baroreflexes; leaves open clinical relevance for orthostatic intolerance.
Does lidocaine infusion alter cardiovascular reflex responses to simulated orthostatic stress in healthy volunteers?
p-value: p=< 0.05
Lidocaine at therapeutic serum levels depresses cardiopulmonary and arterial baroreflexes when both are unloaded, which may have important therapeutic consequences for patients with previously impaired baroreflex functions.
Duranteau et al. (1991) studied Healthy volunteers. Lidocaine vs. Saline was evaluated on Changes in heart rate, forearm vascular resistance, plasma noradrenaline, and plasma renin activity at a LBNP of -40 mm Hg (p=< 0.05). Lidocaine significantly decreased the induced rises in heart rate, forearm vascular resistance, plasma noradrenaline, and plasma renin activity during high-level simulated orthostatic stress (p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: