Why the study?
Does intravenous lidocaine affect myocardial contractility and baroreflex control of heart rate in conscious dogs?
Population
Conscious dogs, previously instrumented for measurements of arterial and left ventricular pressures…
Comparison
Intravenous lidocaine vs Baseline before lidocaine infusion
Design
Preclinical
Follow-up
30 minutes
Authors
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May caution against assuming neutral hemodynamics with lidocaine in conscious subjects; leaves open translation of canine autonomic modulation to humans.
Does intravenous lidocaine affect myocardial contractility and baroreflex control of heart rate in conscious dogs?
Therapeutic plasma levels of lidocaine have direct depressant effects on cardiac chronotropism and inotropism, which are modulated by central stimulation of the autonomic nervous system in conscious dogs.
Edouard et al. (1986) studied this question.
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